學 習 工 作 經 歷 |
1988.09-1992.07 太原工業(yè)大學,,精細化工專業(yè),,獲工學學士學位 2000.09-2003.06 太原理工大學,應用化學專業(yè),,獲工學碩士學位 2007.09-2012.07 山西醫(yī)科大學,,勞動衛(wèi)生與環(huán)境衛(wèi)生學專業(yè),獲醫(yī)學博士學位 2003.07-今山西醫(yī)科大學藥學院講師,、副教授,、教授、博導 2024.01-今 山西醫(yī)科大學,,教育部慢性腎臟病醫(yī)藥基礎研究創(chuàng)新中心,,副主任 |
主 要 學 術 成 就 |
2022年,以主要完成人獲批治療糖尿病腎病國家1類化學新藥“LM49片”藥物臨床試驗批準通知書1項,。2023年,,“LM49片”的臨床批件和相關知識產權以1.1億元成功轉讓。主持“新藥創(chuàng)制”國家科技重大專項課題1項,,山西省重點研發(fā)計劃(重點)項目課題2項,、山西省煤基重點科技攻關項目課題1項、山西省自然科學基金2項,、山西省高等學??萍紕?chuàng)新項目1項、山西醫(yī)科大學科技創(chuàng)新基金1項,、山西醫(yī)科大學博士啟動基金1項,、教育部慢性腎臟病醫(yī)藥基礎研究創(chuàng)新中心專項基金重點項目1項、山西中醫(yī)藥大學基于炎性反應的重大疾病創(chuàng)新藥物省重點實驗室開放課題1項,,指導山西省創(chuàng)新創(chuàng)業(yè)訓練項目1項,,主持山西醫(yī)科大學教改項目1項。授權日本發(fā)明專利1項,、中國發(fā)明專利11項,;受理中國發(fā)明專利2項。在國內外學術刊物上發(fā)表學術論文40余篇,,其中,,20余篇被SCI收錄。獲山西省科技進步二等獎1項,。2023年度校優(yōu)秀教師,。參編國家級規(guī)劃教材8部。 |
代表性論文 |
[1]Fan Yang, Yingjie Gao, Siyi Xie, Wenjing Yang, Qiyan Wang, Wenqian Ye, Lu Sun, Jiangtao Zhou*,XiuE Feng*. Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota. Food Funct. 2025. DOI: 10.1039/d4fo06043a. [2]Xiu E Feng, Tai Gang Liang, Jie Gao, De Peng Kong, Rui Ge, Qing Shan Li*.Heme Oxygenase-1, a Key Enzyme for the Cytoprotective Actions of Halophenols by Upregulating Nrf2 Expression via Activating Erk1/2 and PI3K/Akt in EA.hy926 Cells. Oxidative Medicine and Cellular Longevity. 2017, ID 7028478. [3]Hong-Xia Yuan1,Xiu-E Feng1, En-Li Liu, Rui Ge, Yuan-Lin Zhang, Bao-Guo Xiao, Qing-Shan Li*. 5,2′‐Dibromo‐2,4′,5′‐trihydroxydiphenylmethanone attenuates LPS‐induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction.J Cell Mol Med. 2018. 1-11. DOI: 10.1111/jcmm.13948. (共同第一作者) [4]Yuan Lin Zhang1,Xiu E. Feng1, Rong Rong Chang, Le Hua Zhang, Bao Guo Xiao, Qing Shan Li*, Xu Liang Hao. Therapeutic effects of 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone (LM49) in an experimental rat model of acute pyelonephritis by immunomodulation and anti-inflammation.International Immunopharmacology. 2018.62.155-164. (共同第一作者) [5]Xiu E Feng, Ke Meng Cui, Qing Shan Li*, Zi Cheng Wu, Fei Lei. Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2’-Dibromo-2,4’,5’-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug.Molecules. 2020. 45, 468. [6]Xiu E Feng, Wan Yi Zhao, Shu Rong Ban, Cheng Xiao Zhao, Qing Shan Li*, Wen Han Lin. Structure–activity relationship of halophenols as a new class of protein tyrosine kinase inhibitors. Int. J. Mol. Sci. 2011, 12(9): 6104-6115. |