主 要 學(xué) 術(shù) 成 就 |
在天然產(chǎn)物活性成分及其作用機(jī)制領(lǐng)域進(jìn)行了持續(xù)性研究，對(duì)狼毒大戟中松香烷二萜的絕對(duì)構(gòu)型進(jìn)行了深入研究，為同類化合物的絕對(duì)構(gòu)型測(cè)定提供了依據(jù),；對(duì)云實(shí)的化學(xué)成分進(jìn)行了深入研究,，從中分離得到了五個(gè)新化合物；對(duì)川楝子的化學(xué)成分及其活性進(jìn)行了深入研究,，從中分離得到了35個(gè)檸檬苦素類化合物，其中新化合物25個(gè)，并對(duì)其神經(jīng)活性進(jìn)行了研究,；目前正在對(duì)蝙蝠葛中的生物堿成分進(jìn)行系統(tǒng)分離并對(duì)其雙靶點(diǎn)抗AD活性進(jìn)行深入研究。主持完成兩項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目，四項(xiàng)省級(jí)科研項(xiàng)目以及多項(xiàng)校級(jí)科研項(xiàng)目,，以第一作者或通訊作者發(fā)表學(xué)術(shù)論文15篇,，其中SCI收錄11篇，授權(quán)實(shí)用新型專利三項(xiàng),。 |
代表性論文 |
(1). Qiong Zhang*, Jing Yu Liang, Qing Shan Li, Zhi Da Min, New limonoids from the fruits of Melia toosendan, Chinese Chemical Letters, 2010, 21(7), 838-841. (2). Qiong Zhang*, Jian-Kuan Li , Rui Ge , Jing-Yu Liang , Qing-Shan Li , Zhi-Da Min, Novel NGF-potentiating limonoids from the fruits of Melia toosendan, Fitoterapia, 2013, 90,192-198. (3). ZHANG Qiong*, ZHENG Qing-Hong, SANG Yi-Shu, SUNG Herman Ho-Yung, MIN Zhi-Da, New limonoids from the bark of Melia toosendan, Chinese Journal of Natural Medicines, 2018, 16(12), 946–950. (4). Min Li, Xu Li, Ian D. Williams, Herman H-Y. Sung, Zhi-Da Min, and Qiong Zhang*, Absolute Configuration of the Butenolide of Abietane, HETEROCYCLES, 2020, 100(4), 559-567. (5). Jiangtao Zhou, Hao Wu, Jing Hou, Jun Wang, Jiajing Wang, Min Li, Xiaojuan Yao, Jianping Gao, Qiong Zhang*, Daurisoline alleviated experimental colitis in vivo and in vitro: Involvement of NF-κB and Wnt/β-Catenin pathway, International Immunopharmacology, 2022, 108, 108714. |
