學(xué) 習(xí) 工 作 經(jīng) 歷 |
2020.12~今 山西醫(yī)科大學(xué),，藥學(xué)院，教授 2011.07~2020.12 山西醫(yī)科大學(xué),，藥學(xué)院,，副教授 2005.07~2011.06 山西醫(yī)科大學(xué),，藥學(xué)院,，講師 2007.09~2012.06 山西醫(yī)科大學(xué),，藥學(xué)院,，博士 2003.07~2005.06 山西醫(yī)科大學(xué),，藥學(xué)院,，助教 2000.09~2003.06 太原理工大學(xué)，化學(xué)化工學(xué)院生物與制藥工程系,，碩士 1988.09~1992.06 太原理工大學(xué),，應(yīng)用化學(xué)系，本科 |
主 要 學(xué) 術(shù) 成 就 |
主要從事藥物設(shè)計(jì)合成及機(jī)制研究,，近年來(lái)主持國(guó)家科技重大專(zhuān)項(xiàng)課題1項(xiàng),，山西省重點(diǎn)研發(fā)計(jì)劃（重點(diǎn)）項(xiàng)目課題1項(xiàng)、山西省煤基重點(diǎn)科技攻關(guān)課題1項(xiàng),、山西省自然科學(xué)基金2項(xiàng),、山西省高等學(xué)校科技創(chuàng)新項(xiàng)目1項(xiàng),、山西醫(yī)科大學(xué)科技創(chuàng)新基金1項(xiàng),、山西醫(yī)科大學(xué)博士啟動(dòng)基金1項(xiàng)、山西中醫(yī)藥大學(xué)基于炎性反應(yīng)的重大疾病創(chuàng)新藥物省重點(diǎn)實(shí)驗(yàn)室2021年度開(kāi)放課題1項(xiàng),，指導(dǎo)山西省創(chuàng)新創(chuàng)業(yè)訓(xùn)練項(xiàng)目1項(xiàng),，主持山西醫(yī)科大學(xué)教改項(xiàng)目1項(xiàng)。作為第二負(fù)責(zé)人,，完成“863”課題2項(xiàng),、國(guó)家自然科學(xué)基金1項(xiàng)、國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放基金2項(xiàng),、山西省歸國(guó)留學(xué)人員基金1項(xiàng),，校企合作項(xiàng)目1項(xiàng)。獲山西省科技進(jìn)步二等獎(jiǎng)1項(xiàng),。授權(quán)日本發(fā)明專(zhuān)利1項(xiàng),，國(guó)家發(fā)明專(zhuān)利11項(xiàng)，在國(guó)內(nèi)外學(xué)術(shù)刊物上發(fā)表學(xué)術(shù)論文30余篇,，其中,，20余篇被SCI收錄。參編國(guó)家級(jí)規(guī)劃教材6部,。 |
代表性論文 |
1. Xiu E Feng, Ke Meng Cui, Qing Shan Li*, Zi Cheng Wu, Fei Lei. Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2’-Dibromo-2,4’,5’-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug. Molecules. 2020. 45, 468. 2. Xiu E Feng, Tai Gang Liang, Jie Gao, De Peng Kong, Rui Ge, Qing Shan Li*. Heme Oxygenase-1, a Key Enzyme for the Cytoprotective Actions of Halophenols by Upregulating Nrf2 Expression via Activating Erk1/2 and PI3K/Akt in EA.hy926 Cells. Oxidative Medicine and Cellular Longevity. 2017, ID 7028478. 3. Xiu E Feng, De Peng Kong, Shu Rong Ban, Rui Ge, Qing Shan Li*. Fluorophenols bearing nitrogenated heterocycle moieties, a class of novel Keap1-Nrf2 protein-protein interaction inhibitors: synthesis, antioxidant stress screening and molecular docking. Medicinal Chemistry Research, 2019. 28(8), 1319-1337. 4. Xiu E. Feng, Qin Jin Wang, Jie Gao, Shu Rong Ban, Qing Shan Li*. Synthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking. Molecules. 2017. 22. 2142. 5. Xiu E Feng, Wan Yi Zhao, Shu Rong Ban, Cheng Xiao Zhao, Qing Shan Li*, Wen Han Lin. Structure–activity relationship of halophenols as a new class of protein tyrosine kinase inhibitors. Int. J. Mol. Sci. 2011, 12(9): 6104-6115 |
